Potassium Carbonate → N-allyl-N-(4-methoxyphenyl)acrylamide
反応式
[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].C([O-])([O-])=O.[K+].[K+].[C:19](Cl)(=[O:22])[CH:20]=[CH2:21]>C(Cl)Cl>[CH2:1]([N:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)[C:19](=[O:22])[CH:20]=[CH2:21])[CH:2]=[CH2:3]参加物
5
実験手順
To a solution of N-allyl-4-methoxyaniline (1.00 g, 6.13 mmol) in methylene chloride (20 mL) was added K2CO3 (2.12 mg, 15.3 mmol) and acryloyl chloride (548 μL, 6.74 mmol) at 0° C. After 15 min., the reaction was quenched with NaHCO3 (5 mL, sat. aq.) and the organic layer was isolated, concentrated and subjected to flash chromatography (Hexanes:EtOAc 4:1) to yield N-allyl-N-(4-methoxyphenyl)acrylamide (1.29 mg, 97%).
後処理
- customthe reaction was quenched with NaHCO3 (5 mL, sat. aq.)
- customthe organic layer was isolated
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b0a5e65cd8714ebf9680a1454527ca05
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067415B2
反応ノート
読み込み中…