関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Fluorophenol | HCID 9743 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromoacetamide | HCID 69632 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(3-Fluorophenoxy)acetamide | HCID 18938105 | — |
反応手順
A mixture of 3-fluorophenol (5.61 g, 50.0 mmol), 2-bromoacetamide (7.59 g, 55.0 mmol) and K2CO3 (13.82 g, 100 mmol) in acetone (80 mL) was stirred at 70° C. overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid. (7.89 g, 93%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434695B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-d042b1f6f2d84485ba161d8dcf4563bd |
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| 出典メモ | uspto-grants-2016_09 |
|---|
