反应详情

温度

70 °C

A mixture of 3-fluorophenol (5.61 g, 50.0 mmol), 2-bromoacetamide (7.59 g, 55.0 mmol) and K2CO3 (13.82 g, 100 mmol) in acetone (80 mL) was stirred at 70° C. overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid. (7.89 g, 93%)

1. temperatureThe mixture was cooled to rt
2. filtrationfiltered
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)