Triethylamine → 4-Methylsulfanyl-[2,2']bipyridinyl-6-carbonitrile
反応式
[CH3:1][S:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[N+:6]([O-])=[CH:7][CH:8]=1.P([C:24]#[N:25])(=O)(OCC)OCC.C(N(CC)CC)C>C(#N)C>[CH3:1][S:2][C:3]1[CH:8]=[C:7]([C:24]#[N:25])[N:6]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH:4]=1参加物
5
実験手順
4-Methylsulfanyl-[2,2′]bipyridinyl 1-oxide (480 mg, 2.20 mmol) was treated under nitrogen with diethyl phosphorocyanidate and triethylamine in dry acetonitrile following a described procedure (I. Antonioni; G. Cristalli; P. Franchetti; M. Grifantini; S. Martelli, Il Farmaco, 1986, 41, 346-354). Crystallization in ethyl acetate afforded 4-methylsulfanyl-[2,2′]bipyridinyl-6-carbonitrile as a white solid (360 mg, 72% yield)
後処理
- customCrystallization in ethyl acetate
出典と根拠
- ORDレコード
- ord-fbfb6f82d4c141a4855306a2a2c7e8ca
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067441B2
反応ノート
読み込み中…