関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromoacetamide | HCID 69632 | — |
| 反応物 | m-Ethynylphenol | HCID 139144 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(3-Ethynylphenoxy)acetamide | HCID 90022913 | 90.1% |
反応手順
A mixture of 3-ethynylphenol (3.31 g, 28.0 mmol), 2-bromoacetamide (2.36 g, 17.1 mmol) and K2CO3 (5.53 g, 40.0 mmol) in acetone (50 mL) was stirred at 70° C. for 7 h. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (2.70 g, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434695B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-3d1810a9000d4b76afffa196398b8754 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
