3-Fluorophenol → Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

HRID 56294

反応式

HRID 56294 の反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[C:10]([F:17])([F:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CO>[F:16][C:10]([F:17])([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12]

参加物

5

反応物 3

HCID 97433-FluorophenolHCID 11430Potassium CarbonateHCID 69585Ethyl bromodifluoroacetate

生成物 1

HCID 66455005Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

後処理

  1. temperatureIt was then cooled to rt
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-47bd33ea822e493bb4ab17fa47d0f8ef
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

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