Methyl morpholine oxide → 2-Bromo-5-(trifluoromethyl)benzaldehyde

HRID 563458

反応式

HRID 563458 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH2:12][OH:13].C[N+]1([O-])CCOCC1>C(Cl)Cl.CC#N.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[CH:12]=[O:13]

参加物

6

反応物 2

HCID 82029Methyl morpholine oxideHCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcohol

生成物 1

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehyde

試薬・触媒・溶媒 3

HCID 178419074HCID 178419074、化合物触媒HCID 6342Acetonitrile溶媒HCID 6344Dichloromethane溶媒

実験手順

To (2-bromo-5-trifluoromethyl-phenyl)-methanol (2.216 g, 8.69 mmol) and N-methylmorpholine N-oxide (2.051 g, 17.38 mmol) in CH2Cl2 (44 mL) and MeCN (2.2 mL) was added tetrapropylammonium perruthenate (0.311 g, 0.87 mmol), and the reaction was stirred at room temperature for 20 minutes. Once no starting material was seen by analytical tlc, the mixture was concentrated and purified by silica gel chromatography to give the title compound.

後処理

  1. concentrationthe mixture was concentrated
  2. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-a84132280b5843aa8010af3d068a986f
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

関連ノート

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