Acetonitrile → 1-[2-Bromo-5-(trifluoromethyl)phenyl]ethan-1-one

HRID 563505ノート

反応式

HRID 563505 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH:12]([OH:14])[CH3:13].C[N+]1([O-])CCOCC1.CC#N>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:11])[F:9])=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13]

参加物

6

反応物 3

HCID 6342AcetonitrileHCID 82029Methyl morpholine oxideHCID 574587951-(2-Bromo-5-(trifluoromethyl)phenyl)ethanol

生成物 1

HCID 574587961-[2-Bromo-5-(trifluoromethyl)phenyl]ethan-1-one

試薬・触媒・溶媒 2

HCID 178419074HCID 178419074、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

1-(2-Bromo-5-trifluoromethyl-phenyl)-ethanol (0.914 g, 3.40 mmol), N-methylmorpholine N-oxide (0.731 g, 6.24 mmol), and tetrapropylammonium perruthenate (0.109 g, 0.31 mmol) were combined in CH2Cl2 (18 mL) and MeCN (0.9 mL) and stirred at room temperature for 30 minutes. Once no starting material was seen by analytical LCMS, the mixture was filtered through Celite and purified by silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound.

後処理

  1. filtrationthe mixture was filtered through Celite
  2. custompurified by silica gel chromatography (0-100% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-d9fb8eb71a984664b489ebe5c104494c
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

反応ノート

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