Hydrogen Bromide → 3-Bromo-4-hydroxyphenylacetic acid

HRID 563530

反応式

HRID 563530 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8]C.Br>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[OH:8]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 1366153-Bromo-4-methoxyphenylacetic acid

生成物 1

HCID 27696283-Bromo-4-hydroxyphenylacetic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3-Bromo-4-methoxyphenylacetic acid (1.3 g, 5.6 mmol) was heated in a solution of hydrogen bromide (3 mL) and acetic acid (3 mL) at 100° C. overnight. The mixture was then partitioned between EtOAc and H2O, and the aqueous layer was separated and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound.

後処理

  1. customThe mixture was then partitioned between EtOAc and H2O
  2. customthe aqueous layer was separated
  3. extractionextracted with EtOAc
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-aa313f2ce17b461c8e45403b4c2cb189
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

関連ノート

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