(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 563551ノート

反応式

HRID 563551 の反応式
[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([O:15]CC2C=CC=CC=2)[CH:6]=1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:14])[F:13])[CH:8]=[C:7]([OH:15])[CH:6]=1

参加物

4

反応物 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

生成物 1

HCID 59644745(3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester (4.8 mmol) in EtOH was treated with 10% palladium on carbon (10% by weight), and stirred under a balloon of H2 at 60° C. overnight. The mixture was filtered to remove the palladium, and then concentrated to give the title compound.

後処理

  1. filtrationThe mixture was filtered
  2. customto remove the palladium
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-2475c029a7d74009a6c469174bb1c4f8
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

反応ノート

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