HCID 66606831、化合物 → HCID 66607287、化合物
反応式
[CH2:1]([O:3][C:4](=[O:39])[CH:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][N:26](C(OCC2C=CC=CC=2)=O)[CH2:27][CH3:28])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:39])[CH:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][NH:26][CH2:27][CH3:28])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]参加物
4
実験手順
To a solution of 2-{2′-[(benzyloxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-propionic acid ethyl ester (0.11 mmol) in EtOH (12 mL) was added 10% palladium on carbon (0.050 g), and the reaction was stirred under a balloon of H2 at room temperature for 1 hour. The mixture was filtered through a pad of Celite and rinsed with EtOH. The filtrate was concentrated to give the title compound.
後処理
- filtration