反応式
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].C(N(C(C)C)CC)(C)C.[C:20](Cl)([Cl:22])=[O:21]>C(Cl)Cl>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:20]([Cl:22])=[O:21])[CH3:2]参加物
5
反応条件
- 温度
- 0 °C
実験手順
N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (20% in toluene; 2.4 mL, 4.6 mmol) was added, and the reaction was stirred overnight at room temperature. The mixture was concentrated, and the residue was dissolved in Et2O and washed twice with H2O. The organic layer was dried, filtered, and concentrated to give the title compound.
後処理
- concentrationThe mixture was concentrated
- dissolutionthe residue was dissolved in Et2O
- washwashed twice with H2O
- customThe organic layer was dried
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2fabad5641c5426cae656d4326331fa4
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067445B2
関連ノート
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