1,8-Diazabicyclo(5.4.0)undec-7-ene → (1S,3R,4R)-methyl 3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-4-hydroxycyclopentanecarboxylate

HRID 56388

反応式

HRID 56388 の反応式
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]3[C:17]([Cl:18])=[C:16]([O:19][CH3:20])[CH:15]=[C:14]([O:21][CH3:22])[C:13]=3[Cl:23])[CH:8]=2)[N:3]=1.[NH2:24][C@H:25]1[C@H:29]([OH:30])[CH2:28][CH:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]1.C1CCN2C(=NCCC2)CC1>C(#N)C.CCOC(C)=O>[Cl:18][C:17]1[C:16]([O:19][CH3:20])=[CH:15][C:14]([O:21][CH3:22])=[C:13]([Cl:23])[C:12]=1[C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:24][C@H:25]1[C@H:29]([OH:30])[CH2:28][C@@H:27]([C:31]([O:33][CH3:34])=[O:32])[CH2:26]1)[N:11]=[CH:10]2

参加物

6

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 899217722-Chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolineHCID 118041469methyl (3R,4R)-3-amino-4-hydroxy-cyclopentanecarboxylate

生成物 1

HCID 118036470(1S,3R,4R)-methyl 3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-4-hydroxycyclopentanecarboxylate収率 67.8%

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
65 °C

実験手順

2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (0.576 g, 1.558 mmol), methyl (3R,4R)-3-amino-4-hydroxycyclopentane-1-carboxylate (0.372 g, 2.337 mmol) were taken up in acetonitrile (3 ml) and DBU (0.470 ml, 3.12 mmol) was added. The reaction was purged with N2 for 5 minutes then heated to 65° C. overnight. After cooling to room temperature, the solvent was removed under reduced pressure. The residue was purified via flash chromatography (0-100% Hex/EtOAc; 12 g column), and (1S,3R,4R)-methyl 3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-4-hydroxycyclopentanecarboxylate (0.520 g, 1.056 mmol, 67.8% yield) was recovered. MS (ES+) C23H23Cl2N3O5 requires: 492, found: 493 [M+H]+.

後処理

  1. customThe reaction was purged with N2 for 5 minutes
  2. temperatureAfter cooling to room temperature
  3. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-18577f484c0a489aa3234c21a76ea822
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

関連ノート

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