Sodium Hydroxide → HCID 67005012、化合物

反応式

[CH3:1][S:2][CH:3]([O:11][C:12]1[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=1)[C:4]([O:6]C(C)(C)C)=[O:5].[OH-].[Na+]>CO.O>[CH3:1][S:2][CH:3]([O:11][C:12]1[CH:13]=[C:14]([Cl:19])[CH:15]=[C:16]([Cl:18])[CH:17]=1)[C:4]([OH:6])=[O:5]

参加物

実験手順

To the product of Step 1 (0.2 g) in methanol (3 ml) at ambient temperature was added a solution of sodium hydroxide (0.050 g) in water (1 ml). The reaction was stirred for 2 hours, the solvent evaporated then water and ethyl acetate were added. The aqueous phase was separated, acidified with dilute aqueous hydrochloric acid then extracted with ethyl acetate. The organic phases were combined, dried over magnesium sulphate, filtered and evaporated to give 2-methylthio-2-(3,5-dichlorophenoxy)acetic acid as a pale yellow gum (0.153 g) that was used in the next step without further purification.