Water → 1-Methyl-1H-indazol-5-ol

HRID 563893

反応式

HRID 563893 の反応式
N[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2.[OH2:12].[OH-].[Na+]>P(=O)(O)(O)O>[OH:12][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2

参加物

5

反応物 3

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 27680321-methyl-1H-indazol-5-amine

生成物 1

HCID 441192401-Methyl-1H-indazol-5-ol

試薬・触媒・溶媒 1

HCID 1004Phosphoric Acid溶媒

反応条件

温度
180 °C

実験手順

5-Amino-1-methylindazole (1.56 g) in phosphoric acid (13 ml) containing water (3 ml) was heated to 180° C. for 18 hours, cooled to ambient temperature, poured into water (5 ml) then neutralised with aqueous sodium hydroxide. The solid that precipitated was filtered from solution, washed with cold water then sucked to dryness to give was hydrolysed to give 5-hydroxyl-1-methylindazole as a brown solid, (1.18 g).

後処理

  1. temperaturecooled to ambient temperature
  2. customThe solid that precipitated
  3. filtrationwas filtered from solution
  4. washwashed with cold water
  5. customto give

出典と根拠

ORDレコード
ord-00365a0cbbd14c7a905837875a647ed6
出典データセット
uspto-grants-2011_11
特許番号
US08067592B2

関連ノート

読み込み中…