Benzoyl chloride, 2-chloro-5-nitro- → 2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

HRID 563998ノート

反応式

HRID 563998 の反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([NH2:10])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:11][C:12]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:13]=1[C:14](Cl)=[O:15]>N1C=CC=CC=1.ClCCl>[Cl:11][C:12]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:13]=1[C:14]([NH:10][C:8]1[CH:9]=[C:4]2[CH:3]=[CH:2][NH:1][C:5]2=[N:6][CH:7]=1)=[O:15]

参加物

5

反応物 2

HCID 117637Benzoyl chloride, 2-chloro-5-nitro-HCID 117151871H-pyrrolo(2,3-b)pyridin-5-amine

生成物 1

HCID 670082132-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

1.87 g 1H-Pyrrolo[2,3-b]pyridin-5-ylamine in 60 ml dry pyridine were treated dropwise at RT with a solution of 6.79 g 2-chloro-5-nitrobenzoyl chloride in 10 ml dichloromethane. Stirring was continued over night. The mixture was evaporated and the residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT. The solvents are again evaporated and the residue is dispersed in water. The crude product is isolated by filtration and washed thoroughly with water and diethylether.

後処理

  1. waitwas continued over night
  2. customThe mixture was evaporated
  3. additionthe residue was treated with 25 ml methanol and 10 ml conc. ammonia for 2 hrs at RT
  4. customThe solvents are again evaporated
  5. additionthe residue is dispersed in water

出典と根拠

ORDレコード
ord-b130c912c1e941c7a65caef297bdae47
出典データセット
uspto-grants-2011_11
特許番号
US08067599B2

反応ノート

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