Trifluoroacetic acid → 5-Benzyloxy-2-[2-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-ethyl]-2H-pyridazin-3-one

HRID 564187ノート

反応式

HRID 564187 の反応式
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:18][CH2:19][N:20]3[C:25](=[O:26])[CH:24]=[C:23]([O:27][CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[CH:22]=[N:21]3)=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:28]([O:27][C:23]1[CH:22]=[N:21][N:20]([CH2:19][CH2:18][C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9]3)=[CH:14][CH:13]=2)[C:25](=[O:26])[CH:24]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 670069227-[2-(4-Benzyloxy-6-oxo-6H-pyridazin-1-yl)-ethyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 580427515-Benzyloxy-2-[2-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-ethyl]-2H-pyridazin-3-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 30 mg (0.06 mmol) 7-[2-(4-benzyloxy-6-oxo-6H-pyridazin-1-yl)-ethyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (example 25.1a) in 2.0 mL DCM is added 50 μL trifluoroacetic acid at RT. The solvent is evaporated and the residue is purified via reverse HPLC chromatography (Waters SunFire, C18; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 10:90).

後処理

  1. customThe solvent is evaporated
  2. customthe residue is purified via reverse HPLC chromatography (Waters SunFire, C18; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 10:90)

出典と根拠

ORDレコード
ord-1e4d054e569e4d5e92469cbbfb1f8953
出典データセット
uspto-grants-2011_11
特許番号
US08067590B2

反応ノート

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