Pyrrolidine → 6-Benzyloxy-3-[2-oxo-2-(4-pyrrolidin-1-ylmethyl-phenyl)-ethyl]-3H-pyrimidin-4-one

HRID 564201ノート

反応式

HRID 564201 の反応式
[CH2:1]([O:8][C:9]1[N:14]=[CH:13][N:12]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Br)=[CH:20][CH:19]=2)=[O:17])[C:11](=[O:26])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>CN(C=O)C>[CH2:1]([O:8][C:9]1[N:14]=[CH:13][N:12]([CH2:15][C:16](=[O:17])[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[CH:20][CH:19]=2)[C:11](=[O:26])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 580427116-Benzyloxy-3-[2-(4-bromomethyl-phenyl)-2-oxo-ethyl]-3H-pyrimidin-4-one

生成物 1

HCID 580427856-Benzyloxy-3-[2-oxo-2-(4-pyrrolidin-1-ylmethyl-phenyl)-ethyl]-3H-pyrimidin-4-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 52 mg (0.13 mmol) 6-benzyloxy-3-[2-(4-bromomethyl-phenyl)-2-oxo-ethyl]-3H-pyrimidin-4-one (preparation 20b) in 2.00 mL of DMF is added 42 μL (0.50 mmol) pyrrolidine. The reaction mixture is stirred 30 min at RT and is directly purified by HPLC (Waters Xbridge; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 0:100).

後処理

  1. customis directly purified by HPLC (Waters Xbridge; water (0.1% formic acid)/acetonitrile (0.1% formic acid) 95:5 to 0:100)

出典と根拠

ORDレコード
ord-7ed935ba06f84b10a78d198352458686
出典データセット
uspto-grants-2011_11
特許番号
US08067590B2

反応ノート

読み込み中…