化工社化工社 化学情報印刷レポート · 研究参考用
6-Methoxy-3-pyridinylamine → m-(Trifluoromethyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| 反応物 | N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide | HCID 16722463 | — |
| 生成物 | m-(Trifluoromethyl)benzamide | HCID 74535 | — |
反応手順
N-[2-({3R)-1-[1-(3-ethoxyphenyl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, substituting 3-ethoxyaniline for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 519 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067457B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-6cd952fe66ec4153a64a02fbd3677703 |
| 出典メモ | uspto-grants-2011_11 |