Bromine → 5-Bromo-2-methoxybenzonitrile

HRID 564455

反応式

HRID 564455 の反応式
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>C(Cl)(Cl)Cl>[Br:1][C:10]1[CH:11]=[CH:12][C:5]([O:4][CH3:3])=[C:6]([CH:9]=1)[C:7]#[N:8]

参加物

4

反応物 2

HCID 24408BromineHCID 810862-Methoxybenzonitrile

生成物 1

HCID 44185605-Bromo-2-methoxybenzonitrile収率 71.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Bromine (13.7 g, 86.0 mmol) in CHCl3 (20 mL) was added to the solution of 2-(methyloxy)benzonitrile (10.9 g, 81.9 mmol) in CHCl3 (50 mL). The mixture was refluxed for 29 h. The reaction was allowed to cool to room temperature, and washed with saturated sodium bisulfite (50 mL), and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate. Evaporation of the solvent afforded 5-bromo-2-(methyloxy)benzonitrile (12.4 g, 71%).

後処理

  1. temperatureThe mixture was refluxed for 29 h
  2. washwashed with saturated sodium bisulfite (50 mL), and brine (50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-14736655450840e29eadb95eeb1761f1
出典データセット
uspto-grants-2011_11
特許番号
US08067408B2

関連ノート

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