(2-Amino-5-bromo-4-chlorophenyl)methanol → 2-Amino-5-bromo-4-chlorobenzaldehyde

HRID 56455

反応式

HRID 56455 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 67081018(2-Amino-5-bromo-4-chlorophenyl)methanol

生成物 1

HCID 894196802-Amino-5-bromo-4-chlorobenzaldehyde収率 83.6%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (2-amino-5-bromo-4-chlorophenyl)methanol (6 g, 25.5 mmol) and manganese(IV) oxide (15.5 g, 0.178 mol) in dichloromethane (100 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (5 g, 81%). MS (ES+) C7H5BrClNO requires: 233, 235, found: 234, 236 [M+H]+.

後処理

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6c416bf047144bc99092021fcac746e0
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

関連ノート

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