N-bromobutanimide → 2-Amino-5-bromo-3-fluorobenzoic acid
反応式
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]参加物
4
実験手順
A solution of 2-amino-3-fluorobenzoic acid (10.85 g, 70 mmol) in dichloromethane (175 mL) was added N-bromosuccinimide (12.46 g, 70 mmol), and the mixture was stirred at room temperature for 2 hours. The precipitate was filtered and washed with dichloromethane (100 mL*3) to give the title compound (12.7 g, 78%) as a grey solid, which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO2 requires: 233, 235, found: 232, 234 [M+H]+.
後処理
- filtrationThe precipitate was filtered
- washwashed with dichloromethane (100 mL*3)
出典と根拠
- ORDレコード
- ord-b4471c6e3f3b489f9ebd1151cd0d9116
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434700B2
反応ノート
読み込み中…