Borohydride → (2-Amino-4-methoxyphenyl)methanol
反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[BH4-]>C1COCC1>[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[CH2:4][OH:5]参加物
4
実験手順
To a solution of 2-amino-4-methoxybenzoic acid (15.0 g, 89.8 mmol) in THF (300 mL) was added borohydride in THF (450 mL, 450 mmol) at 0° C., and the reaction mixture was stirred at room temperature overnight. The reaction was quenched with water (150 mL) and extracted with ethyl acetate (500 mL×3). The organic layers were separated, combined, washed with water (200 mL) and brine (200 mL), dried over sodium sulfate, filtered and concentrated to afford the title compound. MS (ES+) C8H11NO2 requires: 153, found: 154 [M+H]+.
後処理
- customThe reaction was quenched with water (150 mL)
- extractionextracted with ethyl acetate (500 mL×3)
- customThe organic layers were separated
- washwashed with water (200 mL) and brine (200 mL)
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-03dc6c37871a47b2ace4fcc0f778d0f7
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434700B2
反応ノート
読み込み中…