Sodium Sulfate → 2-Amino-5-bromo-4-methoxybenzaldehyde

HRID 56482

反応式

HRID 56482 の反応式
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Br:12]N1C(=O)CCC1=O.S([O-])([O-])(=O)=O.[Na+].[Na+]>ClCCl.O>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

6

反応物 3

HCID 24436Sodium SulfateHCID 67184N-bromobutanimideHCID 3235032-Amino-4-methoxybenzaldehyde

生成物 1

HCID 593252582-Amino-5-bromo-4-methoxybenzaldehyde収率 56%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231, found: 230, 232 [M+H]+.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-1203a7025ae741efb01dce4fb28ead02
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

関連ノート

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