1-(4-Bromo-3,5-dimethoxyphenyl)ethanol → 1-(4-Bromo-3,5-dimethoxyphenyl)ethan-1-one
反応式
[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([CH:10]([OH:12])[CH3:11])=[CH:4][C:3]=1[O:13][CH3:14]>C(Cl)Cl.O=[Mn]=O>[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10](=[O:12])[CH3:11])=[CH:4][C:3]=1[O:13][CH3:14]参加物
4
実験手順
To a solution of 1-(4-bromo-3,5-dimethoxyphenyl)ethanol (10.8 g, 41.1 mmol) in anhydrous CH2Cl2 (150 mL) was added MnO2 (48 g, 552 mmol). After the mixture was placed under a drying tube and stirred at room temperature for 22 hours, it was filtered through a pad of Celite and silica gel and rinsed with EtOAc. Concentration of the filtrate in vacuo gave 1-(4-bromo-3,5-dimethoxyphenyl)ethanone as a white solid (10.3 g, 97% yield). The product was used without further purification.
後処理
- customAfter the mixture was placed under a drying tube
- filtrationit was filtered through a pad of Celite and silica gel
- washrinsed with EtOAc
出典と根拠
- ORDレコード
- ord-e65aa7e78a474896a277627b84544fcd
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434707B2
反応ノート
読み込み中…