Methanol → potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate

HRID 56495

反応式

HRID 56495 の反応式
[N:1]1([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[CH:14](Br)(Br)Br.[OH-:18].[K+:19].[CH3:20][OH:21]>O1CCOCC1>[N:1]1([C:6]2[CH:13]=[CH:12][C:9]([CH:10]([O:11][CH3:14])[C:20]([O-:21])=[O:18])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[K+:19]

参加物

6

反応物 4

HCID 887Methanol2 回HCID 5558BromoformHCID 14797Potassium HydroxideHCID 27764774-(1H-Pyrazol-1-yl)benzaldehyde

生成物 1

HCID 67388986potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a stirred solution of 4-(1H-pyrazol-1-yl)benzaldehyde (1.3 g, 7.55 mmol) and bromoform (0.85 mL, 9.75 mmol) in MeOH (10 mL) and dioxane (10 mL) was added dropwise a solution of potassium hydroxide (2.2 g, 39 mmol) in MeOH (10 mL) over 15 minutes. Stirring was then continued for 23 hours. The mixture was filtered through Celite, rinsed through with EtOAc and concentrated under reduced pressure to yield potassium 2-(4-(1H-pyrazol-1-yl)phenyl)-2-methoxyacetate as a light yellow solid (3.2 g) that was used without further purification. See U.S. Pat. No. 7,129,238.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. washrinsed through with EtOAc
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-034ed94b6f7243d68a696cd0661a86e9
出典データセット
uspto-grants-2016_09
特許番号
US09434707B2

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