Methanol → HCID 178485129、化合物

HRID 565011

反応式

C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](C(OC)=O)=[CH:3]1.[ClH:15].[NH2:16][C:17]([NH2:19])=[NH:18].[CH3:20][O-:21].[Na+].[CH3:23]O>>[ClH:15].[CH3:23][NH:18][C:17]([NH:19][C:20]([C:3]1[NH:2][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)=[O:21])=[NH:16]

参加物

反応物 4

HCID 887Methanol

HCID 5742Guanidine Hydrochloride

HCID 842006Methyl 1-methyl-1H-indole-3-carboxylate

HCID 10942334Sodium Methoxide

生成物 1

HCID 178485129HCID 178485129、化合物収率 35.9%

実験手順

The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.29 mmol) of methyl 1-methyl-3-indolecarboxylate, 5.05 g (52.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.85 g (52.9 mmol) of sodium methoxide. Thus 0.48 g (35.9%) of 1-methyl-3-indoloylguanidine hydrochloride was obtained.

出典と根拠

ORDレコード: ord-f7001c65f3be46fe82e08b468c8e63d2
出典データセット: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06169107A

反応式

参加物

反応物 4

生成物 1

実験手順

出典と根拠

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