Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine

HRID 565116

反応式

HRID 565116 の反応式
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 224515665-Acetoxy-2-methoxypyridine

生成物 1

HCID 116223355-Hydroxy-2-methoxypyridine収率 53.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the 5acetoxy-2-methoxypyridine (600 mg, 3.59 mmol) in MeOH (10 mL) was added 1M aq. NaOH (10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combind CHCl3 extracts were washed with H2O, dried (anhydrous MgSO4) and evaporated to give the title compound as a brown oil (240 mg, solidified on standing).

後処理

  1. customvolatile solvent was removed in vacuo
  2. extractionextracted with CHCl3(3×)
  3. washThe combind CHCl3 extracts were washed with H2O
  4. dry with materialdried (anhydrous MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-7a0e6f87b72e498c8d540f671597e5da
出典データセット
uspto-grants-2001_01
特許番号
US06169188A

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