Water → 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone

HRID 565122

反応式

HRID 565122 の反応式
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][CH:6]([CH2:10][CH3:11])[C:7](Cl)=[O:8].[C:12]1([S:18][CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>C(Cl)(Cl)Cl>[CH3:19][S:18][C:12]1[CH:17]=[CH:16][C:15]([C:7](=[O:8])[CH:6]([CH3:5])[CH2:10][CH3:11])=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 962WaterHCID 7520ThioanisoleHCID 93697Butanoyl chloride, 2-methyl-HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 154806432-Methyl-1-[4-(methylthio)phenyl]-1-butanone

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a suspension of AlCl3 (35.4 g) in CHCl3 (500 mL) at −10° C. was added dropwise 2-methylbutyryl chloride (3.13 g) followed by thioanisole (31.2 mL). The mixture was then stirred at r.t. for 20 min. and was then cooled back to 0° C. Water (200 mL) was then added over 30 min. The CHCl3 layer was separated and dried over MgSO4. After filtration and removal of the solvent, the residue was dried under vacuum at 80° C. for 2 h to give 35 g of the title compound.

後処理

  1. temperaturewas then cooled back to 0° C
  2. customThe CHCl3 layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationAfter filtration and removal of the solvent
  5. customthe residue was dried under vacuum at 80° C. for 2 h

出典と根拠

ORDレコード
ord-ff075d93be0940fda5eaf795e081ca95
出典データセット
uspto-grants-2001_01
特許番号
US06169188A

関連ノート

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