Morpholine → 6-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

HRID 565195ノート

反応式

HRID 565195 の反応式
[N:1]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12]C)=O.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCCC1>[N:14]1([C:10]([C:2]2[CH:3]=[CH:4][C:5]([C:7]([O:9][C:5]([CH3:7])([CH3:6])[CH3:4])=[O:8])=[CH:6][N:1]=2)=[O:12])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 425561312,5-Pyridinedicarboxylic acid, 2-methyl ester

生成物 1

HCID 100857186-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

For example, the 2,5-pyridinedicarboxylic acid, 2-methyl ester, 5-t-butyl ester 15 is contacted with a molar excess of morpholine in an appropriate organic solvent, such as tetrahydrofuran. The reaction is typically conducted at a temperature range of from room temperature to reflux and for a period of time ranging from 5 hours to 3 days. The 6-(morpholine-4-carbonyl)nicotinic acid, t-butyl ester 16 is isolated from the reaction mixture by standard extractive methods as is known in the art and may be purified by crystallization.

後処理

  1. customis typically conducted at a temperature range of from room temperature
  2. temperatureto reflux and for a period of time
  3. waitranging from 5 hours to 3 days

出典と根拠

ORDレコード
ord-9a23fe2e8d8f48b882c5385cdb3440b3
出典データセット
uspto-grants-2001_01
特許番号
US06172044B2

反応ノート

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