2-(4-Methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester → 2-(4-Methoxy-benzenesulfonyl)3-phenyl-propionic acid

HRID 565284ノート

反応式

HRID 565284 の反応式
C([O:3][C:4](=[O:24])[CH:5]([S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)(=[O:15])=[O:14])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>CO.[OH-].[Na+]>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([S:13]([CH:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([OH:24])=[O:3])(=[O:15])=[O:14])=[CH:21][CH:20]=1

参加物

4

反応物 1

HCID 108934292-(4-Methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester

生成物 1

HCID 108709182-(4-Methoxy-benzenesulfonyl)3-phenyl-propionic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a stirred solution of 2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester (348 mg, 1 mmol) in methanol (25 ml), 10 N NaOH (10 ml) was added. The reaction mixture was stirred at room temperature for 48 hours. At the end, the reaction mixture was concentrated and carefully neutralized with dilute HCl. The residue obtained was extracted with chloroform, washed well with water, dried and concentrated. The product obtained was purified by silica-gel column chromatography by eluting with ethyl acetate: methanol (95:5) to afford 2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionic acid as a colorless oil. Yield: 250 mg, 89%; MS: 321 (M+H)+.

後処理

  1. concentrationAt the end, the reaction mixture was concentrated
  2. customThe residue obtained
  3. extractionwas extracted with chloroform
  4. washwashed well with water
  5. customdried
  6. concentrationconcentrated
  7. customThe product obtained
  8. customwas purified by silica-gel column chromatography
  9. washby eluting with ethyl acetate: methanol (95:5)

出典と根拠

ORDレコード
ord-d8e31223ef394304ace3546533794716
出典データセット
uspto-grants-2001_01
特許番号
US06172057B2

反応ノート

読み込み中…