Potassium Hydroxide → 4-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

HRID 565603ノート

反応式

HRID 565603 の反応式
[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12](N)=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:25].[K+]>C(O)CO.O.C(O)(=O)C>[CH2:1]([N:8]1[CH2:16][CH2:15][C:11]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)([C:12]([OH:25])=[O:13])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 2

HCID 14797Potassium HydroxideHCID 211931981-Benzyl-4-(3-methylphenylamino)isonipecotamide

生成物 1

HCID 211934454-(m-Toluidino)-1-benzylpiperidine-4-carboxylic acid

試薬・触媒・溶媒 3

HCID 174Ethylene Glycol溶媒HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

A solution of 1-benzyl-4-(3-methylphenylamino)isonipecotamide (4.5 g, 13.9 mmol), as described above in Example 2, Step B, and potassium hydroxide (3.g, 53.5 mmol) in ethylene glycol (35 mL) was heated under reflux. The resulting mixture was diluted with water and neutralized with acetic acid. The white solid precipitated was filtered, washed with chloroform to provide 1-benzyl-4-(3-methylphenylamino)piperidine-4-carboxylic acid.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux
  3. customThe white solid precipitated
  4. filtrationwas filtered
  5. washwashed with chloroform

出典と根拠

ORDレコード
ord-f737e724aa864c3fbe88e766adc1a39b
出典データセット
uspto-grants-2001_01
特許番号
US06172076B2

反応ノート

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