Water → 4,4-Diphenylbutan-1-ol

HRID 565650ノート

反応式

HRID 565650 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([CH:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:14][CH2:15][C:16](O)=[O:17])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O.[OH-].[Na+]>C(OCC)C>[C:19]1([CH:13]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:14][CH2:15][CH2:16][OH:17])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 2743834,4-Diphenylbutanoic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 925194,4-Diphenylbutan-1-ol収率 99.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

In 70 mL of ice-cooled diethyl ether was suspended 1.9 g of lithium aluminum hydride, followed by dropwise addition of a solution of 4,4-diphenylbutyric acid (6.0 g) in diethyl ether (50 mL). After completion of dropwise addition, the mixture was refluxed for 2 hours and, then, allowed to cool. To this reaction mixture, 1.9 mL of water, 1.9 mL of 15% aqueous sodium hydroxide, and 5.7 mL of water were added in the order mentioned and the mixture was stirred at room temperature for 30 minutes. The precipitate was filtered off and the filtrate was concentrated to provide 5.6 g of the title compound. Yield 99%.

後処理

  1. additionAfter completion of dropwise addition
  2. temperaturethe mixture was refluxed for 2 hours
  3. temperatureto cool
  4. filtrationThe precipitate was filtered off
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-70974a9ac1214b46ae7221f29d3a0010
出典データセット
uspto-grants-2001_01
特許番号
US06172085B2

反応ノート

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