Indole → 1-Phenyl-1H-indole
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(=O)(O)[O-].[K+]>BrC1C=CC=CC=1.[Cu]I>[C:4]1([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH:3]=[CH:2]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
A suspension of indole (8.2 g), potassium bicarbonate (12 g) and copper (I) iodide (2.7 g) in bromobenzene (70 mL) was refluxed for 3 hours under nitrogen atmosphere. To the mixture copper (I) iodide (11 g) was added and the mixture was refluxed for additional 6 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1 to 20:1) to provide 8.4 g of the title compound. Yield 62%.
後処理
- temperaturewas refluxed for 3 hours under nitrogen atmosphere
- temperaturethe mixture was refluxed for additional 6 hours
- customThe insoluble material was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
- customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1 to 20:1)
出典と根拠
- ORDレコード
- ord-df943a1910d34487b1cad511b5518662
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06172085B2
反応ノート
読み込み中…