(S)-mandelic acid → HCID 70239495、化合物

反応式

[CH3:1][C@H:2]([N:9]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:10]1[C:11]([O:13][CH3:14])=[O:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:19]([OH:29])(=[O:28])[C@H:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[OH:21]>C(OC)(C)(C)C>[C:19]([OH:29])(=[O:28])[C@H:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[OH:21].[CH3:1][C@H:2]([N:9]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:10]1[C:11]([O:13][CH3:14])=[O:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

実験手順

Methyl N-[(S)-α-methylbenzyl]-(RS)-pipecolate (157 mg) was dissolved in methyl tert-butyl ether (2 ml) at room temperature. To this solution was added a mixture of L-(+)-mandelic acid (86 mg) and methyl tert-butyl ether (2 ml) at room temperature and stirred. The resulting solution was allowed to stand at −20° C. for one day to form a crystal. The crystals were separated by filtration and dried to yield an L-(+)-mandelic acid salt of methyl N-[(S)-α-methylbenzyl]-(S)-pipecolate (79.9 mg) in an optical purity of 73% de and a yield of 23%.