1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline

HRID 565831

反応式

HRID 565831 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 7835411-(4-Nitrobenzyl)piperidine

生成物 1

HCID 8461504-(Piperidin-1-ylmethyl)aniline収率 18.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

In ethanol (50 ml) was dissolved 1-(4-nitrobenzyl)piperidine (6.41 g), and 10% dried palladium on carbon (0.33 g) was added to the mixture. Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 24 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from hexane to give 1-(4-aminobenzyl)piperidine (1.01 g) as pale yellow crystals.

後処理

  1. additionwas added to the mixture
  2. filtrationThe palladium was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-503b4ff6a8fa4e7798c018ced35f5f00
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

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