1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline
反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1参加物
4
実験手順
In ethanol (50 ml) was dissolved 1-(4-nitrobenzyl)piperidine (6.41 g), and 10% dried palladium on carbon (0.33 g) was added to the mixture. Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 24 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from hexane to give 1-(4-aminobenzyl)piperidine (1.01 g) as pale yellow crystals.
後処理
- additionwas added to the mixture
- filtrationThe palladium was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from hexane
出典と根拠
- ORDレコード
- ord-503b4ff6a8fa4e7798c018ced35f5f00
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06172061B2
反応ノート
読み込み中…