Methyl iodide → SB 227122
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[CH2:17][CH2:16][CH2:15][C:14]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([CH2:27][N:28]([CH:30]5[CH2:35][CH2:34][O:33][CH2:32][CH2:31]5)[CH3:29])=[CH:23][CH:22]=4)=[O:19])=[CH:13][C:12]=3[CH:36]=2)=[CH:4][CH:3]=1.[CH3:37][I:38]>CN(C)C=O>[I-:38].[CH3:29][N+:28]([CH3:37])([CH2:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:18]([C:14]2[CH2:15][CH2:16][CH2:17][C:11]3[CH:10]=[CH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=4)=[CH:36][C:12]=3[CH:13]=2)=[O:19])=[CH:22][CH:23]=1)[CH:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1参加物
4
実験手順
A solution of 2-(4-methylphenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5 H-benzocycloheptene-8-carboxamide (0.11 g) and methyl iodide (0.02 ml) in dimethylformamide (4 ml) was stirred at room temperature over night. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which was recrystallized from ethanol-ethyl acetate to give N,N-dimethyl-N-(4-((2-(4-methylphenyl)-6,7-dihydro-5 H-benzocyclohepten-8-yl)carbonyl)aminobenzyl)-N-(4-tetrahydropyranyl)ammonium iodide (Compound 220) (0.13 g) as pale yellow crystals.