1-Methyl-4-[(4-nitrobenzyl)sulfonyl]benzene → 4-[[(4-Methylphenyl)sulfonyl]methyl]benzenamine

HRID 565977

反応式

HRID 565977 の反応式
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([CH2:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:6][CH:5]=1)([O-])=O>C(O)C.C(OCC)(=O)C.[Pd]>[CH3:18][C:15]1[CH:14]=[CH:13][C:12]([S:9]([CH2:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:20][CH:19]=2)(=[O:11])=[O:10])=[CH:17][CH:16]=1

参加物

5

反応物 1

HCID 8000821-Methyl-4-[(4-nitrobenzyl)sulfonyl]benzene

生成物 1

HCID 15084184-[[(4-Methylphenyl)sulfonyl]methyl]benzenamine収率 89.2%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

In ethanol (10 ml) and ethyl acetate (60 ml) was dissolved 4-methylphenyl 4-nitrobenzyl sulfone (0.5 g; G. Bram et al., Synthesis, 1987, 56-59). To the mixture was added 10% palladium on carbon (0.05 g) and catalytic hydrogenation was carried out at room temperature over night. The catalyst was filtered off, and the solvent was evaporated to give 4-aminobenzyl 4-methylphenyl sulfone (0.4 g) as colorless crystals.

後処理

  1. waitwas carried out at room temperature over night
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-28f07e2f5e11418885a539f27448c718
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

関連ノート

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