Hydrochloric Acid → 6-(4-Methylphenyl)-2-methylquinoline-3-carboxylic acid

HRID 566033ノート

反応式

HRID 566033 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[C:13]([CH3:18])[C:12]([C:19]([O:21]C)=[O:20])=[CH:11]3)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O1CCCC1CCO>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[C:13]([CH3:18])[C:12]([C:19]([OH:21])=[O:20])=[CH:11]3)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18472437Methyl 6-(4-methylphenyl)-2-methylquinoline-3-carboxylate

生成物 1

HCID 229902036-(4-Methylphenyl)-2-methylquinoline-3-carboxylic acid収率 68.8%

試薬・触媒・溶媒 1

HCID 119895722-(Oxolan-2-yl)ethan-1-ol溶媒

実験手順

To a solution of methyl 6-(4-methylphenyl)-2-methylquinoline-3-carboxylate (0.99 g) in tetrahydrofuranethanol (5-5 ml) was added 2N sodium hydroxide (2 ml) at room temperature, and the mixture was stirred for 2 days. To the reaction mixture was added 1N hydrochloric acid (4 ml), and the mixture was concentrated under reduced pressure to precipitate crystals, which were collected by filtration and washed with ethanol and diethylether to give 6-(4-methylphenyl)-2-methylquinoline-3-carboxylic acid (648 mg) as colorless crystals.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customto precipitate crystals, which
  3. filtrationwere collected by filtration
  4. washwashed with ethanol and diethylether

出典と根拠

ORDレコード
ord-7ee45ee01ccb4e8d811b5a0e08d35870
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

反応ノート

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