Hydrochloric Acid → 7-(3,4-Methlenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid

HRID 566105ノート

反応式

HRID 566105 の反応式
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[O:19][CH2:18][CH2:17][C:16]([C:20]([O-:22])=[O:21])=[CH:15][C:14]=4[CH:23]=3)=[CH:4][C:3]=2[O:2]1.[OH-].[Na+].Cl>CO>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[O:19][CH2:18][CH2:17][C:16]([C:20]([OH:22])=[O:21])=[CH:15][C:14]=4[CH:23]=3)=[CH:4][C:3]=2[O:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 184722037-(3,4-Methylenedioxy-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxylate

生成物 1

HCID 184722047-(3,4-Methlenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In methanol (5 ml) was suspended 7-(3,4-methylenedioxy-phenyl)-2,3-dihydro-1-benzoxepine-4-carboxylate (399 mg, 1.23 mmol), and to the mixture was added 1N sodium hydroxide solution (3.69 ml). The mixture was stirred at room temperature for 20 hours, and to the mixture was added 1N hydrochloric acid (3.69 ml). The mixture was concentrated under reduced pressure, and to the residue was added water. Insoluble materials were filtered, which were washed with water and diethylether and dried under reduced pressure to give 7-(3,4-methylenedioxyphenyl)-2,3-dihydro-1-benzoxepine-4-carboxylic acid(321 mg, 1.03 mmol, 84%).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionto the residue was added water
  3. filtrationInsoluble materials were filtered
  4. washwhich were washed with water and diethylether
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f7b7673fdc32498e86fa0983c1aa8487
出典データセット
uspto-grants-2001_01
特許番号
US06172061B2

反応ノート

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