5-(4-nitrophenyl)-3H-1,3-oxazol-2-one → 5-(4-Aminophenyl)-1,3-oxazol-2(3H)-one

HRID 56615

反応式

HRID 56615 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13](=[O:15])[NH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:14][C:13](=[O:15])[NH:12][CH:11]=2)=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 8221335-(4-nitrophenyl)-3H-1,3-oxazol-2-one

生成物 1

HCID 1176227935-(4-Aminophenyl)-1,3-oxazol-2(3H)-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 1.1 g (5.4 mmol) of 5-(4-nitrophenyl)-1,3-oxazol-2(3H)-one in 40 ml of ethanol was hydrogenated in the presence of 111 mg of palladium (10% on activated carbon) at RT and standard pressure for 5 d. The reaction mixture was then filtered through Celite and the residue was washed with ethanol. The combined filtrates were concentrated under reduced pressure. The residue was used for the next step without further purification. Yield: 626 mg (purity 88%, 58% of theory)

後処理

  1. filtrationThe reaction mixture was then filtered through Celite
  2. washthe residue was washed with ethanol
  3. concentrationThe combined filtrates were concentrated under reduced pressure
  4. customThe residue was used for the next step without further purification

出典と根拠

ORDレコード
ord-30bea0a6042a4218bea4e67ef947e621
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

読み込み中…