Water → HCID 21265864、化合物

HRID 566255ノート

反応式

HRID 566255 の反応式
[CH:1]1[N:2]=[C:3]([CH2:10][C:11](OC)=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[BH4-].[Na+].O>CO>[CH:1]1[N:2]=[C:3]([CH2:10][CH2:11][OH:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21265856HCID 21265856、化合物

生成物 1

HCID 21265864HCID 21265864、化合物収率 88.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

Methyl 2-(imidazo[1,5-a]pyridin-3-yl)acetate (1.85 g) was dissolved in methanol (30 ml). To the solution was added sodium borohydride (3.68 g), and the mixture was stirred for one hour at 60° C. To the reaction mixture was added water (20 ml), which was concentrated under reduced pressure. The concentrate was subjected to extraction twice with ethyl acetate (40 ml). The organic layers were combined and dried over anhydrous magnesium sulfate, followed by concentration to afford the title compound (1.39 g).

後処理

  1. concentrationwas concentrated under reduced pressure
  2. extractionThe concentrate was subjected to extraction twice with ethyl acetate (40 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationfollowed by concentration

出典と根拠

ORDレコード
ord-8bb3c0dc0e4743dfb19d1f1c560f125f
出典データセット
uspto-grants-2001_01
特許番号
US06174877B1

反応ノート

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