Lithium Hydroxide → 1-[(Tert-butoxy)carbonyl]-4-ethylpiperidine-4-carboxylic acid

HRID 566410ノート

反応式

HRID 566410 の反応式
C([O:3][C:4](=[O:20])[C:5]1([CH2:18][CH3:19])[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1)C.[OH-].[Li+]>C(O)C>[C:14]([O:13][C:11]([N:8]1[CH2:9][CH2:10][C:5]([CH2:18][CH3:19])([C:4]([OH:20])=[O:3])[CH2:6][CH2:7]1)=[O:12])([CH3:17])([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 53393415Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

生成物 1

HCID 221690971-[(Tert-butoxy)carbonyl]-4-ethylpiperidine-4-carboxylic acid収率 45.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester (570 mg) in ethanol (10 ml) was added a 1M lithium hydroxide solution (8 ml), and the mixture was refluxed under heating for 20 hours. Then, the reaction mixture was concentrated, and water was added to the residue. The aqueous layer was washed with ether, acidified with 1N hydrochloric acid, and extracted with ether. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (233 mg, yield 45%).

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 20 hours
  3. concentrationThen, the reaction mixture was concentrated
  4. additionwater was added to the residue
  5. washThe aqueous layer was washed with ether
  6. extractionextracted with ether
  7. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-12634d9262c8429abd611d9741319fa7
出典データセット
uspto-grants-2001_01
特許番号
US06174887B1

反応ノート

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