Methyl L-phenylalaninate hydrochloride → HCID 86756228、化合物

HRID 566414ノート

反応式

HRID 566414 の反応式
[Cl:1][C:2]1[C:3]([OH:13])=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[OH:11])[C:5]([OH:7])=O.Cl.[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH2:19].CCN=C=N[CH2:33][CH2:34][CH2:35][N:36]([CH3:38])C.Cl.[CH:40]1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[ClH:1].[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:19][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([Cl:12])[C:10]([O:11][CH2:40][CH2:33][CH2:34][CH2:35][NH:36][CH3:38])=[C:2]([Cl:1])[C:3]=1[OH:13]

参加物

7

反応物 4

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 3042133beta-Resorcylic acid, 3,5-dichloro-

生成物 1

HCID 86756228HCID 86756228、化合物収率 95%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

To a solution of 3,5-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, Step 5) to give the title compound (18.32 g, yield 57%).

後処理

  1. additionThen, the mixture was post-treated in the same manner as in the above Example 1, Step 5)

出典と根拠

ORDレコード
ord-085fae59107b4fb8a96c6fe0afb59b3b
出典データセット
uspto-grants-2001_01
特許番号
US06174887B1

反応ノート

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