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2,5-Dichlorobenzeneboronic acid → Tert-butyl 2-(4-(2,5-dichlorophenyl)-2-oxopyridin-1(2h)-yl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dichlorobenzeneboronic acid | HCID 2773371 | — |
| 反応物 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate | HCID 117622807 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 生成物 | Tert-butyl 2-(4-(2,5-dichlorophenyl)-2-oxopyridin-1(2h)-yl)propanoate | HCID 117622663 | — |
反応手順
2.5 g (8.0 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate (racemate) and 1.76 g (9.2 mmol) of 2,5-dichlorophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 2.3 g (77% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-6ec48d2ebcd54656ae66b98aa0225caf |
| 出典メモ | uspto-grants-2016_09 |