4-Bromo-2-hydroxypyridine → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate

HRID 56651

反応式

HRID 56651 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.Br[CH:10]([CH2:18][CH3:19])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:10]([CH2:18][CH3:19])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:4](=[O:8])[CH:3]=1

参加物

3

反応物 2

HCID 8171154-Bromo-2-hydroxypyridineHCID 13124118tert-Butyl 2-bromobutanoate

生成物 1

HCID 117622861tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)butanoate

実験手順

348 mg (2.0 mmol) of 4-bromopyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromobutanoate (racemate) were reacted according to General Method 4B at 120° C. After aqueous work-up, the desired product was reacted further as crude product. Yield: 608 mg (purity 82%, 79% of theory)

後処理

  1. customaccording to General Method 4B at 120° C

出典と根拠

ORDレコード
ord-14b2ea9e819e44e5aba150649ad2e6ec
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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