Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → tert-Butyl 4-{[2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoyl]amino}benzoate

HRID 56667

反応式

HRID 56667 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:8]([CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:9]([OH:11])=O)[C:4](=[O:16])[CH:3]=1.[NH2:17][C:18]1[CH:30]=[CH:29][C:21]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:8]([CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:9]([NH:17][C:18]2[CH:30]=[CH:29][C:21]([C:22]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:23])=[CH:20][CH:19]=2)=[O:11])[C:4](=[O:16])[CH:3]=1

参加物

3

反応物 2

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl esterHCID 1176225472-(4-Bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid

生成物 1

HCID 117622557tert-Butyl 4-{[2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoyl]amino}benzoate

実験手順

290 mg (purity 94%, 0.95 mmol) of 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoic acid (racemate) and 1.1 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. Yield: 114 mg (purity 80%, 21% of theory)

出典と根拠

ORDレコード
ord-af942e16b44b47fdb42c1a87322408b8
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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