Dimethyl Sulfoxide → 3-[2-(Trifluoromethyl)phenoxy]phthaionitrile

HRID 566845

反応式

HRID 566845 の反応式
[N+]([C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=1[C:12]#[N:13])([O-])=O.[F:14][C:15]([F:24])([F:23])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[OH:22].C(=O)([O-])[O-].[K+].[K+].CS(C)=O>O>[F:14][C:15]([F:23])([F:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[O:22][C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[C:5]=1[C:12]#[N:13]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 11430Potassium CarbonateHCID 679582-TrifluoromethylphenolHCID 1626521,2-Benzenedicarbonitrile, 3-nitro-

生成物 1

HCID 702187873-[2-(Trifluoromethyl)phenoxy]phthaionitrile収率 93.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A reaction flask equipped with a cooling tube was loaded with 8.7 g of 3-nitrophthalonitrile, 9.4 g of 2-(trifluoromethyl)phenol, 13.8 g of anhydrous potassium carbonate and 350 ml of dimethyl sulfoxide, and the temperature was raised to 50° C. with stirring under nitrogen flow. After stirring at 50° C. for three hours, the heating was stopped. The reaction liquid was cooled and added into 500 ml of water, and the precipitated crystal was collected and dried to yield 13.5 g of the intended compound.

後処理

  1. customA reaction flask equipped with a cooling tube
  2. stirringAfter stirring at 50° C. for three hours
  3. customThe reaction liquid
  4. temperaturewas cooled
  5. customthe precipitated crystal was collected
  6. customdried

出典と根拠

ORDレコード
ord-94338cd70cd04a0594a4c0519c257649
出典データセット
uspto-grants-2001_01
特許番号
US06177132B1

関連ノート

読み込み中…