Thionyl Chloride → 3,3-Difluorooxolane-2,5-dione

HRID 566959ノート

反応式

HRID 566959 の反応式
[F:1][C:2]([F:10])([CH2:6][C:7]([OH:9])=[O:8])[C:3](O)=[O:4].S(Cl)(Cl)=O>C1C=CC=CC=1>[F:1][C:2]1([F:10])[CH2:6][C:7](=[O:9])[O:8][C:3]1=[O:4]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 695812,2-Difluorosuccinic acid

生成物 1

HCID 131892433,3-Difluorooxolane-2,5-dione収率 83%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 2,2-difluorosuccinic acid (1.15 g, 7.46 mmol), thionyl chloride (4 mL, 20.6 mmol) and benzene (4 mL) was heated at reflux for 2.5 h. The mixture was filtered and the filtrate was concentrated to afford the title product as an oil that crystallized on standing (838 mg, 6.16 mmol, 83% yield).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-036ddd05d94a4024a6a0c2a972faa8d2
出典データセット
uspto-grants-2001_01
特許番号
US06177445B1

反応ノート

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