Benzyl Bromide → 6-Benzyloxy-2,2-dimethylchroman-4-one

HRID 567054

反応式

HRID 567054 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([CH3:13])([CH3:12])[CH2:6][C:5]2=[O:14].C(=O)([O-])[O-].[K+].[K+].[CH2:21](Br)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(C(CC)=O)C>[CH2:21]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([CH3:12])([CH3:13])[CH2:6][C:5]2=[O:14])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 35198596-Hydroxy-2,2-dimethylchroman-4-one

生成物 1

HCID 117809926-Benzyloxy-2,2-dimethylchroman-4-one

試薬・触媒・溶媒 1

HCID 7288Ethyl ketone溶媒

実験手順

25.2 g (131.2 mmol) of 6-hydroxy-2,2-dimethylchroman-4-one were introduced into 350 ml of diethyl ketone with stirring at RT and, after addition of 18.0 g (131 mmol) of powdered potassium carbonate, stirred at 75° C. for 30 min. After cooling to 60° C., 15.7 ml (131 mmol) of benzyl bromide were added dropwise, the mixture was concentrated in vac. after 2 h, the residue was treated with water and the solid was filtered off with suction, 37 g, m.p. 105-107° C.

後処理

  1. stirringstirred at 75° C. for 30 min
  2. temperatureAfter cooling to 60° C.
  3. concentrationthe mixture was concentrated in vac
  4. additionthe residue was treated with water
  5. filtrationthe solid was filtered off with suction, 37 g, m.p. 105-107° C.

出典と根拠

ORDレコード
ord-67edcac50259407a9861c6f578820c95
出典データセット
uspto-grants-2001_01
特許番号
US06177449B1

関連ノート

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